Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 58504
Gene Symbol: ARHGAP22
ARHGAP22 		0.130 GeneticVariation disease GWASDB Genome-wide association study of diabetic retinopathy in a Taiwanese population. 21310492 2011
Entrez Id: 84898
Gene Symbol: PLXDC2
PLXDC2 		0.120 GeneticVariation disease GWASDB Genome-wide association study of diabetic retinopathy in a Taiwanese population. 21310492 2011
Entrez Id: 114803
Gene Symbol: MYSM1
MYSM1 		0.110 GeneticVariation disease GWASDB Genome-wide association study of diabetic retinopathy in a Taiwanese population. 21310492 2011
Entrez Id: 266722
Gene Symbol: HS6ST3
HS6ST3 		0.110 GeneticVariation disease GWASDB Genome-wide association study of diabetic retinopathy in a Taiwanese population. 21310492 2011
Entrez Id: 9882
Gene Symbol: TBC1D4
TBC1D4 		0.100 GeneticVariation disease GWASDB Genome-wide association study in a Chinese population with diabetic retinopathy. 23562823 2013
Entrez Id: 339529
Gene Symbol: LINC02774
LINC02774 		0.100 GeneticVariation disease GWASDB Genome-wide meta-analysis for severe diabetic retinopathy. 21441570 2011
Entrez Id: 7347
Gene Symbol: UCHL3
UCHL3 		0.100 GeneticVariation disease GWASDB Genome-wide association study in a Chinese population with diabetic retinopathy. 23562823 2013
Entrez Id: 285600
Gene Symbol: KIAA0825
KIAA0825 		0.100 GeneticVariation disease GWASDB Genome-wide association study of diabetic retinopathy in a Taiwanese population. 21310492 2011
Entrez Id: 54715
Gene Symbol: RBFOX1
RBFOX1 		0.100 GeneticVariation disease GWASDB Genome-wide meta-analysis for severe diabetic retinopathy. 21441570 2011
Entrez Id: 4008
Gene Symbol: LMO7
LMO7 		0.100 GeneticVariation disease GWASDB Genome-wide association study in a Chinese population with diabetic retinopathy. 23562823 2013
Entrez Id: 101927155
Gene Symbol: LMO7-AS1
LMO7-AS1 		0.100 GeneticVariation disease GWASDB Genome-wide association study in a Chinese population with diabetic retinopathy. 23562823 2013
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1 		0.600 Therapeutic disease RGD Silybin reduces obliterated retinal capillaries in experimental diabetic retinopathy in rats. 25066112 2014
Entrez Id: 183
Gene Symbol: AGT
AGT 		0.580 Therapeutic disease RGD Despite evidence that hyperactivity of the vasodeleterious axis (ACE/angiotensin II (Ang II)/AT1 receptor) of the renin-angiotensin system (RAS) is associated with the pathogenesis of diabetic retinopathy (DR) use of the inhibitors of this axis has met with limited success in the control of this pathophysiology. 21792177 2012
Entrez Id: 836
Gene Symbol: CASP3
CASP3 		0.510 Biomarker disease RGD Caspase-dependent retinal ganglion cell apoptosis in the rat model of acute diabetes. 19187597 2008
Entrez Id: 7057
Gene Symbol: THBS1
THBS1 		0.500 Biomarker disease RGD Further studies should address the possible involvement of the TSP1 in the pathophysiology of diabetic retinopathy. 17117553 2006
Entrez Id: 4846
Gene Symbol: NOS3
NOS3 		0.300 Biomarker disease RGD Simvastatin increases circulating endothelial progenitor cells and reduces the formation and progression of diabetic retinopathy in rats. 23059402 2012
Entrez Id: 177
Gene Symbol: AGER
AGER 		0.300 Therapeutic disease RGD Puerarin enhances superoxide dismutase activity and inhibits RAGE and VEGF expression in retinas of STZ-induced early diabetic rats. 23146804 2012
Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1 		0.300 Biomarker disease RGD To further test the possible pathogenic role of aldose reductase in the development of diabetic retinopathy, we examined the retinal effects of this structurally novel and highly selective ARI in insulinized streptozotocin-induced diabetic rats. 17003340 2006
Entrez Id: 4846
Gene Symbol: NOS3
NOS3 		0.300 Therapeutic disease RGD Rho kinase inhibition by fasudil ameliorates diabetes-induced microvascular damage. 18840783 2009
Entrez Id: 5176
Gene Symbol: SERPINF1
SERPINF1 		0.300 Biomarker disease RGD The high levels of PEDF in the retina of SDT rats may contribute to the low incidence of neovascular formation and absence of non-perfused areas that do not match the typical diabetic retinopathy in humans. 16054135 2006
Entrez Id: 177
Gene Symbol: AGER
AGER 		0.300 Biomarker disease RGD Retinal upregulation of inflammatory and proangiogenic markers in a model of neonatal diabetic rats fed on a high-fat-diet. 23587252 2013
Entrez Id: 6347
Gene Symbol: CCL2
CCL2 		0.300 Biomarker disease RGD A marked increase in the expression of MCP-1 was detected 4 weeks after STZ injection, and the expression was consistently upregulated at 3 and 5 months in the rodent DR model. 23010641 2012
Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1 		0.300 Biomarker disease RGD Electron microscopic immunocytochemical evidence for the mechanism of blood-retinal barrier breakdown in galactosemic rats and its association with aldose reductase expression and inhibition. 8150024 1993
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A 		0.290 Therapeutic disease RGD Anti-VEGF effects of intravitreal erythropoietin in early diabetic retinopathy. 20515763 2010
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A 		0.290 Biomarker disease RGD Early inner retinal astrocyte dysfunction during diabetes and development of hypoxia, retinal stress, and neuronal functional loss. 22110070 2011